. 2021 Jun 3;15:673003. doi: 10.3389/fnhum.2021.673003

Table 3.

Effect of maturation on DTI parameters in children with DCD^a.

White matter structure		MNI-space			DTI	Direction	t	FWE	Cohen’s d
		X	Y	Z	parameter	of change		Sig
Anterior thalamic radiation L	At anterior corona radiata	−21	31	8	FA	Decreased	3.9	*	0.72
		−24	32	9	MD	Increased	2.5	**	0.46
					RD		4.1	**	0.76
	At anterior limb of internal capsule	−20	17	4	FA	Decreased	3.0	*	0.55
		−12	2	4	MD	Increased	1.3	*	0.24
					RD		3.0	**	0.55
	At posterior limb of internal capsule	−12	−2	6	MD	Increased	2.8	**	0.52
					RD		2.2	**	0.41
	At thalamus	−10	−10	10	MD	Increased	1.5	*	0.27
Anterior thalamic radiation R		25	−35	4	MD	Increased	2.4	**	0.44
					RD		2.2	*	0.40
	At anterior corona radiata	22	31	10	MD	Increased	1.6	*	0.29
					RD		1.9	**	0.36
	At anterior limb of internal capsule	13	1	5	MD	Increased	4.9	**	0.88
					RD		4.6	**	0.66
Sensorimotor tract L	At posterior corona radiata	−25	−25	29	MD	Increased	2.5	*	0.46
					RD		3.8	**	0.70
Sensorimotor tract R	At posterior limb of internal capsule	18	−12	1	MD	Increased	2.9	**	0.54
					RD		2.2	*	0.40
	At thalamus	16	−20	0	MD	Increased	2.9	**	0.48
					RD		2.1	**	0.49
	At pontine crossing	6	−30	−35	MD	Increased	3.9	*	0.71
Inferior fronto-occipital fasciculus L		−23	23	6	MD	Increased	1.9	**	0.35
					RD		2.9	**	0.53
Inferior fronto-occipital fasciculus R		25	23	−7	MD	Increased	1.9	**	0.34
					RD		2.1	**	0.38
		33	−30	5	MD	Increased	3.2	**	0.59
					RD		1.1	*	0.20
Superior longitudinal fasciculus L		−36	−22	29	MD	Increased	1.4	*	0.25
					RD		4.1	**	0.75
Superior longitudinal fasciculus R		39	−36	34	MD	Increased	2.7	*	0.48
					RD		2.2	*	0.40
		31	−53	24	MD	Increased	1.2	*	0.23
					RD		3.4	*	0.62
		43	−46	3	MD	Increased	0.9	*	0.20
					RD		2.2	*	040
		58	−30	−14	MD	Increased	2.8	**	0.51
					RD		3.5	**	0.65
Inferior longitudinal fasciculus L		−29	−30	3	MD	Increased	1.4	*	0.25
					RD		2.4	**	0.43
		−43	−30	−7	MD	Increased	2.2	*	0.40
		−48	−21	−15			3.2	*	0.60
		−43	0	−30			2.8	*	0.50
		−45	−3	−34			1.9	*	0.30
Inferior longitudinal fasciculus R		43	−7	−20	MD	Increased	2.4	**	0.44
					RD		1.9	**	0.36
		48	116	60	MD	Increased	2.4	**	0.43
					RD		3.2	**	0.58
		42	−3	−24	MD	Increased	3.5	**	0.64
					RD		1.9	**	0.34
		45	−15	−10	MD	Increased	2.7	**	0.49
					RD		3.1	**	0.57
		43	−41	−3	MD	Increased	1.9	*	0.34
					RD		2.4	**	0.43
		40	−30	4	MD	Increased	1.9	**	0.34
					RD		4.4	**	0.81
Cingulum L		−8	−25	38	MD	Increased	1.7	*	0.31
					RD		2.0	*	0.37
		−18	−37	38	MD	Increased	2.9	*	0.52
					RD		3.6	*	0.65
Cingulum R		8	−25	38	MD	Increased	2.2	*	0.40
					RD		4.0	*	0.74
		10	−36	37	MD	Increased	2.3	*	0.40
					RD		1.8	*	0.33
Anterior corona radiata R		18	28	−10	MD	Increased	2.1	**	0.40
					RD		1.0	*	0.20
		27	17	18	MD	Increased	1.6	**	0.30
					RD		1.2	*	0.20
Posterior limb of internal capsule R		21	−5	13	MD	Increased	2.5	**	0.46
					RD		5.7	*	0.99
Retrolenticular of internal capsule R		28	−21	−3	MD	Increased	4.2	**	0.76
					RD		4.3	**	0.79
Corpus callosum	Genu	13	32	0	MD	Increased	1.1	**	0.30
Forceps minor		−18	54	6	RD	Increased	2.1	*	0.39
Body		4	12	21	MD	Increased	2.2	**	0.41
					RD		1.9	*	0.35
		0	3	24	MD	Increased	1.5	**	0.27
					RD		1.5	*	0.28
	Splenium	−2	−32	18	MD	Increased	2.3	**	0.43
					RD		1.6	*	0.30
		13	−43	13	MD	Increased	1.8	**	0.32

DCD, developmental coordination disorder; DTI, diffusion tensor imaging; FA, fractional anisotropy; FWE, family-wise error corrected; L, left; MD, mean diffusivity; R, right; RD, radial diffusivity; Sig, significant level. ^aEffects are shown with threshold-free cluster enhancement (TFCE) and a minimum cluster size of 100 voxels. *FWE-p < 0.05; confidence interval: 0.044–0.056. **FWE-p < 0.01; confidence interval: 0.008–0.013.