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The role of CD44 in the regulation of CSC properties. The CD44 gene gives rise to CD44s variant or CD44v variant. CD44s interacts with hyaluronic acid (HA) activating pathways that induce EMT. HA can also bind to CD44v receptor and activate EMT and self-renewal through various pathways. Another ligand osteopontin (OPN) binds specifically to CD44v, which induces EMT and self-renewal.
