Figure 5.

Octamer binding transcriptional factor 4 (OCT4) variants in cancer. (A) The different isoforms and pseudogenes of OCT4 expressed in cancer at the RNA level. The conserved regions are shown in the same color. The dotted lines indicate absence of the region. The sequences inserted are shown in purple or blue boxes. (B) Protein expression of the variants. Conserved amino acid stretches are shown by the same color. The point mutations in the pseudogenes are shown in the figure. (C) The important residues of human OCT4A (POU and TAD domain) that are critical for self-renewal.