FIGURE 5.

Classification accuracy of the 10-gene signature against existing scores. (A) ROC, (B) PRC. Each signature was calculated based on the training patient cohort. The ROR score is based on the PAM50 genes (Parker et al., 2009), invasiveness score is based on 64 invasiveness related genes (Anastassiou et al., 2011), and DX^® DCIS score based on seven genes (Solin et al., 2013). The expression values of the 64 genes were converted to z-score over each gene, and the average z-score was used as the invasiveness score for each sample. The original DX^® DCIS score was based on qPCR data, but here it was applied to microarray gene expression data. The curves show the mean sensitivity and specificity over 10 CV folds in the training cohort. See Supplementary Table 5 for the SD of the AU-ROC and AU-PRC values.