TABLE 2.
Biological processes enriched in mRNAs that exhibited a concordant expression change during trophoblast differentiationa and ranked by adjusted p-value.
| Process |
| Immune response |
| Female pregnancy |
| Signal transduction |
| Inflammatory response |
| Cell surface receptor signaling pathway |
| Immune system process |
| Chemokine-mediated signaling pathway |
| Cell-cell signaling |
| Response to drug |
| Retinoid metabolic process |
| Cytokine-mediated signaling pathway |
| Positive regulation of cytosolic calcium ion concentration |
| Positive regulation of T cell proliferation |
| Defense response |
| Regulation of calcium ion-dependent exocytosis |
| Calcium ion-regulated exocytosis of neurotransmitter |
| Multicellular organism development |
| Cell adhesion |
| Positive regulation of phagocytosis, engulfment |
| Chemotaxis |
| Single organismal cell-cell adhesion |
| Innate immune response |
| Keratinization |
| Cellular response to lipopolysaccharide |
| G-protein coupled receptor signaling pathway |
| Positive regulation of ERK1 and ERK2 cascade |
| Positive regulation of cell proliferation |
aTrophoblast differentiation was defined as expression change in control vs. hypoxia and in control vs. DMSO exposure.