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IBSP‐siRNA inhibited proliferation and induced apoptosis in CRC cells. B: blank, NC: negative control, *p < 0.05, **p < 0.01. (A) Downregulation of IBSP mRNA in CRC cells. (B) IBSP‐siRNA inhibited cell proliferation of CRC cells. (C) IBSP‐siRNA increased apoptosis of CRC cells. (D) The protein level of PCNA, Bcl2/Bax, Cyclin D1, and Cdk4 in CRC cells decreased after transfection with IBSP‐siRNA
