FIGURE 8.

IBSP overexpression promoted CRC cell proliferation, invasion as well as migration via Fyn/β‐catenin pathway. *p < 0.05, **p < 0.01, ***p < 0.001,**** p < 0.0001, ns: nonsignificant. (A) Upregulation of IBSP mRNA in CRC cells. (B) IBSP overexpression promoted cell proliferation of CRC cells. (C) IBSP overexpression significantly increased the number of cell colonies. (D) IBSP overexpression promoted invasion and migration of CRC cells. (E) IBSP overexpression increased the protein level of PCNA, Bcl2, Cyclin D1, Cdk4, MMP2, MMP9, N‐cadherin, Vimentin, Fyn, p‐Fyn, and p‐β‐catenin and decreased the expression of Bax and E‐cadherin