Brain areas where local cortical thickness is associated with the time × cannabis interaction in a linear mixed-effects model analysis, controlling for the main effects of time point, lifetime cannabis use, total brain volume, sex, handedness, Alcohol Use Disorders Identification Test Alcohol Consumption score, and site (N = 799; 1598 magnetic resonance imaging scans). The figure is shown at P ≤ .05 with a whole-brain random field theory correction. Blue shades correspond to areas significant at the cluster level and red shades to areas significant at the vertex level.