Figure 1.
Pharmacokinetic studies in WT and Hbbth3/+ mouse models. Wild type (WT) and β-thalassemic (Hbbth3/+) animals were implanted with murine primary dermal fibroblasts (Fib) overexpressing Epo. Three groups were generated for each genotype (1 × 105, 5 × 105, and 1 × 106 transduced cells). Increased expression of Epo leads to significant increased Hb levels in both WT (A) and Hbbth3/+ (B) mice. As expected, enhanced erythropoiesis was also associated with splenomegaly in WT (C) and worsening of it in β-thalassemic animals (D). Dotted red line indicates mean values for untreated WT mice. Dashed black lines indicates mean values for untreated Hbbth3/+ mice. Bars represent SD. Asterisks refer to statistically significant differences (****P ≤ .001; ***P ≤ .005; **P ≤ .01; *P ≤ .05).