TABLE 4.
Treatment toxicities
| IC+RT arm | CCRT arm | p‐value | |||||||
|---|---|---|---|---|---|---|---|---|---|
| n (%) | n (%) | ||||||||
| Grade 1 | Grade 2 | Grade 3 | Grade 4 | Grade 1 | Grade 2 | Grade 3 | Grade 4 | ||
| Hematological | |||||||||
| Leukopenia | 13 (13.1) | 28 (28.3) | 27 (27.3) | 8 (8.1) | 9 (9.1) | 35 (35.4) | 37 (37.4) | 12 (12.1) | 0.008 |
| Neutropenia | 5 (5.1) | 12 (12.1) | 13 (13.1) | 44 (44.4) | 8 (8.1) | 20 (20.2) | 17 (17.2) | 42 (42.4) | 0.098 |
| Anemia | 46 (46.5) | 25 (25.3) | 9 (9.1) | 0 (0) | 55 (55.6) | 20 (20.2) | 10 (10.1) | 6 (6.1) | 0.015 |
| Thrombocytopenia | 20 (20.2) | 1 (1) | 1 (1) | 0 (0) | 22 (22.2) | 2 (2) | 0 (0) | 0 (0) | 0.846 |
| Nonhematological | |||||||||
| Skin desquamation | 55 (55.6) | 22 (22.2) | 3 (3) | ‐ | 45 (45.5) | 27 (27.3) | 7 (7.1) | ‐ | 0.371 |
| Mucositis | 41 (41.4) | 38 (38.4) | 5 (5.1) | ‐ | 47 (47.5) | 31 (31.3) | 6 (6.1) | ‐ | 0.751 |
| Oral fungal infection | 20 (20.2) | 20(20.2) | 1 | ||||||
| Nausea and vomiting | 16 (16.2) | 13 (13.1) | 1 (1) | ‐ | 20 (20.2) | 13 (13.1) | 1 (1) | ‐ | 0.899 |
Treatment toxicities were categorized and graded according to the NCI CTCAE v.3.0.
Abbreviations: CCRT, concurrent chemoradiotherapy; IC, induction chemotherapy; RT, radiotherapy.