Figure 4.
Mechanisms of topoisomerase II poisons. The two distinct mechanisms, interfacial and covalent, by which compounds can interact with the enzyme-DNA complex to enhance DNA cleavage are described.
Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.