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. Author manuscript; available in PMC: 2021 Jun 17.
Published in final edited form as: Biochemistry. 2021 May 19;60(21):1630–1641. doi: 10.1021/acs.biochem.1c00240

Figure 6.

Figure 6.

Dietary and environmental topoisomerase II poisons. A number of dietary and environmental compounds can act as topoisomerase II poisons. Included on the list of dietary natural products are: genistein (soy), EGCG [(−)-epigallocatechin gallate; green tea], sulforaphane (cruciferous vegetables), oleuropein (olives), curcumin (turmeric), thymoquinone (black seed). On the list of environmental chemicals are: 1,4-benzoquinone (benzene metabolite), PCB (polychlorinated biphenyl) quinone (industrial fluid), and NAPQI (N-acetyl-p-benzoquinone imine; acetaminophen metabolite).