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. 2021 Jun 1;34(2):e14187. doi: 10.1111/nmo.14187

TABLE 3.

Extraintestinal symptoms after resolution of SARS‐CoV‐2 infection according to the Structured Assessment of Gastrointestinal Symptoms Scale (SAGIS) questionnaire

SARS‐CoV‐2 p‐value Adjusted risk ratio p‐value
n (%) (95% confidence interval)
Positive Negative
SAGIS extraintestinal
Headache 33 (20.1%) 61 (33.3%) 0.017 0.68 (0.46; 1.0) 0.05
Back pain 46 (28.0%) 68 (37.2%) 0.185 0.65 (0.47; 0.90) 0.01
Sleep disturbances 63 (38.4%) 59 (32.2%) 0.483 1.23 (0.90; 1.68) 0.19
Chronic fatigue 52 (31.7%) 25 (13.7%) <0.001 2.24 (1.48; 3.37) <0.001
Depression 13 (7.9%) 7 (3.8%) 0.262 1.35 (0.53; 3.45) 0.52
Anxiety disorder 30 (18.3%) 30 (16.4%) 0.745 0.88 (0.53; 1.48) 0.64

Adjusted risk ratios were obtained from multiple Poisson regression models with robust variance containing the covariates sex, age, level of education, past surgery, chronic medications, smoking habits, and psychological comorbidity.