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. 2021 Jun 8;40(16):e107786. doi: 10.15252/embj.2021107786

Figure 4. The complex structures of GD/1/2019 RBD and GX/P2V/2017 RBD bound to hACE2.

Figure 4

  • A
    The overall complex structures of hACE2 bound to the SARS‐CoV‐2 RBD, GD/1/2019 RBD, and GX/P2V/2017 RBD. The binding between the RBDs and hACE2 is mainly composed of two patches of interactions, and patch 1 and patch 2 are indicated in black and red dashed boxes, respectively. The N‐glycans are shown as spheres. hACE2, SARS‐CoV‐2 RBD, GD/1/2019 RBD, and GX/P2V/2017 RBD are colored in cyan, orange, light pink, and pale green, respectively.
  • B, C
    Detailed interaction of hACE2 with the SARS‐CoV‐2 RBD, GD/1/2019 RBD, and GX/P2V/2017 RBD in patch 1 and patch 2. Residues involved in the interaction are labeled, and H‐bonds are shown as red dotted lines with a cutoff of 3.5 Å.