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. 2020 Aug 11;2(3):zcaa016. doi: 10.1093/narcan/zcaa016

Figure 5.

Figure 5.

Effect of gemcitabine position and number of modifications in the sense strand of the siRNA on efficacy and potency of the siRNA/gemcitabine combination. Various unmodified/gemcitabine-modified siRNAs (Table 1) were transfected into BxPC3 (A), MIA PaCa-2 (B) or Huh7 cells (C) at a density of 1000 cells/well in 384-well plates and incubated for 96h. Cell viability was measured using CellTiter-Glo® 2.0 reagent. Data are shown as the mean ± SD for four replicates for each data point. The experiment was replicated three times with similar results. All data are normalized to unmodified NS siRNA treatment (data not shown).