Table 2.

Delafloxacin and comparator activity against S. pneumoniae serotypes

Serotype/antibiotic	MIC50 (mg/L)	MIC90 (mg/L)	MIC range (mg/L)	Susceptible (%)
All S. pneumoniae serotypes (n = 142)
Delafloxacin	0.015	0.015	0.004–0.03	100
Moxifloxacin	0.25	0.25	0.06–0.25	100
Azithromycin	0.25	>32	0.06–>32	76.1
Penicillina	≤0.03	2	≤0.03–4	71.8
Clindamycin	0.06	>32	≤0.015–>32	85.2
Ceftriaxone	0.015	0.5	≤0.008	100
S. pneumoniae serotype 3 (n = 27)
Delafloxacin	0.015	0.03	0.008–0.03	100
Moxifloxacin	0.25	0.25	0.12–0.25	100
Azithromycin	0.12	0.25	0.06–0.25	100
Penicillina	≤0.03	≤0.03	≤0.03–0.06	100
Clindamycin	0.06	0.06	≤0.015–0.12	100
Ceftriaxone	0.015	0.015	≤0.008–0.015	100
S. pneumoniae serotype 19F (n = 14)
Delafloxacin	0.015	0.015	0.004–0.03	100
Moxifloxacin	0.12	0.25	0.12–0.25	100
Azithromycin	0.25	>32	0.12–>32	85.7
Penicillina	0.25	2	≤0.03–2	14.3
Clindamycin	0.06	0.5	0.06–>32	85.7
Ceftriaxone	0.06	0.5	0.015–1	100
S. pneumoniae serotype 23F (n = 10)
Delafloxacin	0.015	0.015	0.004–0.015	100
Moxifloxacin	0.12	0.25	0.06–0.25	100
Azithromycin	2	>32	0.25–>32	40
Penicillina	≤0.03	2	≤0.03–2	50
Clindamycin	0.06	>32	0.06–>32	80
Ceftriaxone	0.12	1	0.015–1	100

^aCLSI oral penicillin breakpoints.²⁰