Figure 1.

Domain composition and structure of human CDK12, CDK13 and CycK proteins. RS, PRM, SR and A correspond to arginine/serine-, proline-, serine- and alanine-rich domains, respectively. The kinase domains and their C-terminal extensions in CDK12 and CDK13 are indicated in dark and light blue, respectively. Numbers below the depictions indicate the amino acid position for a given domain. The regions of the proteins that are predicted to be intrinsically disordered are marked above their schemes.