Skip to main content
. 2020 Mar 3;2(1):zcaa003. doi: 10.1093/narcan/zcaa003

Figure 3.

Figure 3.

CDK12 regulates optimal translation of subset of mRNAs. (Left) CDK12 in collaboration with mTORC1 kinase phosphorylates the translational repressor 4E-BP1, which leads to its release from 5′ cap (black oval)-bound eIF4E. Subsequent recruitment of the eIF4G translation initiation complex to the eIF4E on the subset of mRNAs results in their efficient translation. (Right) CDK12 depletion results in a diminished phosphorylation of 4E-BP1, which stays bound to eIF4E and blocks the recruitment of eIF4G, which prevents the translation of the CDK12-specific subset of mRNAs.