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. 2021 Mar 22;3(1):zcab009. doi: 10.1093/narcan/zcab009

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© The Author(s) 2021. Published by Oxford University Press on behalf of NAR Cancer.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 4. — BMI1 regulates alternative splicing in GBM. (A) MA plots indicating Log2 fold change versus mean expression to show significant genes with DEU (Benjamini–Hochberg adjusted P< 0.05, coloured in red) upon BMI1, PRP6 and CBX8 silencing. (B) Histogram showing number of DEU events and genes with DEU undergoing alternative splicing upon BMI1, PRP6 and CBX8 silencing (Benjamini–Hochberg adjusted P< 0.05). (C) Venn diagram showing common DEU genes upon BMI1 silencing and previously identified prognostically relevant genes with alternative splicing in GBM (AS GBM). (D) Venn diagram showing common DEU genes upon PRP6 silencing and previously identified prognostically relevant AS-GBM genes. (E) Venn diagram showing common and exclusive genes with DEU upon BMI1 and PRP6 silencing and previously identified prognostically relevant AS GBM genes with translation initiation (red) and mRNA binding (blue) as networks enriched for.