Table 1.

Characteristics of cohort

Variable	Frequency, n = 301	%
Age, median (IQR), years	60 (45–68)	—
Female	118	39.2
PWID	21	7.0
Referring service
orthopaedics	114	37.9
medicine	46	15.3
cellulitis clinic	30	10
neurosurgery	21	0.7
cardiovascular surgery	16	5.3
gastroenterology	12	4
cardiology	11	3.7
infectious diseases	10	3.3
otolaryngology	8	2.7
general surgery	6	2
plastic surgery	6	2
thoracic surgery	5	1.7
urology	5	1.7
nephrology	3	1
other	7	2.3
Indications for treatment
infected joint (with or without hardware)	91	30.2
skin and soft tissue infection	44	14.6
osteomyelitis	40	13.3
bacteraemia	34	11.3
surgical site infection (non-joint related)	27	9
endocarditis	22	7.3
meningitis/epidural abscess	16	5.3
intra-abdominal infection	13	4.3
device-related infection (excluding bacteraemia)	8	2.7
pneumonia with S. aureus	2	0.7
other	4	1.3
Isolated microorganisms
MRSA	102	33.9
coagulase-negative Staphylococcus	90	29.9
Enterococcus spp.	20	6.6
MSSA	6	2.0
Cutibacterium acnes	5	1.7
culture negative	68	22.6
other	10	3.3
Concurrent antimicrobial therapy
none	152	50.5
cephalosporin	54	17.9
rifampicin	17	5.6
piperacillin/tazobactam	34	11.3
carbapenem	24	8.0
fluoroquinolone	6	2.0
trimethoprim/sulfamethoxazole	2	0.7
aminoglycosides	2	0.7
metronidazole	2	0.7
tetracycline	1	0.3
clindamycin	1	0.3
antivirals	2	0.7
oral vancomycin	1	0.3
daptomycin	1	0.3
Source of culture specimen
tissue	65	21.6
blood	52	17.3
fluid	22	7.3
urine	1	0.3
wound	67	22.3
historic positive	20	6.6
culture negative	73	24.3
missing	1	0.3
Target level of vancomycin trough level
10–15 mg/L	103	34.2
15–20 mg/L	125	41.5
10–20 mg/L	73	24.2