Table 2.
Subgroup analyses of summary effect sizes by type of bacteria, median year of enrolment, geographical region of study and day of mortality ascertainment
| Sepsis/shock |
Mortality |
|||||
|---|---|---|---|---|---|---|
| n studies (n patients) | OR (95% CI) | I2 (%) | n studies (n patients) | OR (95% CI) | I2 (%) | |
| Overall | 7 (915) | 1.23 (0.75–2.02) | 14.8 | 17 (4473) | 1.70 (1.15–2.49) | 58.3 |
| By bacterial species | ||||||
| E. coli | 3 (619) | 0.99 (0.45–2.22) | 32.7 | 10 (3621) | 1.65 (1.03–2.66) | 62.1 |
| K. pneumoniae, P. mirabilis or E. cloacae | 4 (296) | 1.83 (0.92–3.67) | 0 | 7 (852) | 1.83 (0.92–3.61) | 58.4 |
| By median year of enrolment | ||||||
| year 1999–2009 | 6 (565) | 1.87 (1.05–3.32) | 0 | 10 (1297) | 1.66 (0.90-3.05) | 64.9 |
| year 2010–17 | 1 (350) | 0.79 (0.44–1.43) | — | 7 (3176) | 1.72 (1.09–2.74) | 52.8 |
| By geographical region | ||||||
| Asia | 3 (547) | 0.93 (0.57–1.51) | 0 | 10 (3055) | 1.80 (1.11–2.92) | 57.6 |
| Europe | 4 (439) | 2.51 (1.16–5.43) | 0 | 7 (1418) | 1.50 (0.78–2.86) | 68.5 |
| By mortality day | ||||||
| 14 to 21 day | — | — | — | 3 (396) | 3.60 (2.06–6.30) | 0 |
| 28 to 30 day | 11 (3610) | 1.62 (1.10–2.38) | 48.2 | |||
Bold indicates statistical significance.