Table 4.
Factors related to treatment outcomesa
| Factors | Treatment success, n (%) | Treatment failure, n (%) | P value |
|---|---|---|---|
| Age | |||
| ≥65 years old | 66 (75.0) | 22 (25.0) | 0.042b |
| <65 years old | 42 (91.3) | 4 (8.7) | |
| Gender | |||
| male | 49 (74.2) | 17 (25.8) | 0.107 |
| female | 59 (86.8) | 9 (13.2) | |
| Initial eGFRc | |||
| ≥60 mL/min/1.73 m2 | 36 (87.8) | 5 (12.2) | 0.213 |
| <60 mL/min/1.73 m2 | 69 (76.7) | 21 (23.3) | |
| Department of treatment | |||
| ICU | 2 (11.1) | 16 (88.9) | <0.001b |
| infectious diseases department | 69 (98.6) | 1 (1.4) | |
| others | 37 (80.4) | 9 (19.6) | |
| Presence of septic shock | |||
| no | 103 (90.4) | 11 (9.6) | <0.001b |
| yes | 5 (25.0) | 15 (75.0) | |
| Site of infectiond | |||
| unknown | 27 (90.0) | 3 (10.0) | <0.001b |
| urinary | 35 (92.1) | 3 (7.9) | |
| intra-abdominal | 21 (80.8) | 5 (19.2) | |
| respiratory | 9 (40.9) | 13 (59.1) | |
| skin and soft tissue | 14 (87.5) | 2 (12.5) | |
| Blood culturee | |||
| positive | 42 (79.2) | 11 (20.8) | 0.739 |
| negative | 55 (83.3) | 11 (16.7) | |
| Appropriate empirical antimicrobial agentsf | |||
| yes | 58 (79.5) | 15 (20.5) | 0.874 |
| no | 46 (82.1) | 10 (17.9) | |
| Appropriate dosage (in 73 patients who received appropriate antibiotic agents) | |||
| yes | 30 (96.8) | 1 (3.2) | 0.004b |
| no | 28 (66.7) | 14 (33.3) | |
| Overallf | |||
| appropriate | 29 (96.7) | 1 (3.3) | 0.023b |
| inappropriate | 75 (75.8) | 24 (24.2) | |
a
Based on χ2 test and/or Fisher’s exact test.
b
Statistically significant at 95% CI.
c
Three patients did not have laboratory tests related to serum creatinine, thus we could calculate eGFR values of only the 131 remaining patients.
d
Two patients with sepsis that originated from other sites of infection were excluded from the analysis.
e
The blood cultures were only collected from 119 patients.
f
Empirical antimicrobial therapy were assessed in 129 patients whose microbiological tests were not available at the time of administering antibiotics; 5 other patients were prescribed targeted antimicrobial therapy.