Table 2.
Overview of the RPA modifications and their proposed functions
| RPA subunit and residue | Enzyme | Functional impact |
|---|---|---|
| Phosphorylation | ||
| RPA1-T180 | ATM/ATR | RPA assembly on ssDNA |
| RPA2-S23, -S29 | CDK | Cell cycle progression |
| RPA2-S33 | ATR | Response to genotoxic stress, DNA repair |
| RPA2-T21, -S12, -S4, -S8 | DNA-PK/ATM | Response to genotoxic stress, DNA repair |
| Acetylation | ||
| RPA1-K163 | GCN5, PCAF | Response to UV-induced DNA damage |
| Ubiquitylation | ||
| Multiple lysine residues on RPA1 and RPA2 | RFWD3, PRP15 | ATR activation, HR, interstrand cross-link repair |
| SUMOylation | ||
| RPA1-K449, -K577 | SUMO-2/3 | DSB repair by HR |