Figure 1.

Functional cancer lncRNAs from three sources are integrated in the CLC2. CLC2 only contains lncRNAs annotated by GENCODE. (A) Literature curation with four criteria are used to define ‘literature lncRNAs’. ‘Literature 2017/2018’ indicates curated genes from the original CLC and newly annotated in CLC2, respectively. (B) Transposon insertional mutagenesis screens identify ‘mutagenesis lncRNAs’. (C) Validated hits from CRISPRi proliferation screens are denoted ‘CRISPRi lncRNAs’. ‘non-CLC’ denotes annotated lncRNAs that are not associated with cancer by literature search. Statistical significance calculated by one-sided Fisher's test.