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. 2020 Dec 22;2(4):zcaa035. doi: 10.1093/narcan/zcaa035

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© The Author(s) 2020. Published by Oxford University Press on behalf of NAR Cancer.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 2. — Profiling of ribose methylations and guide RNAs in patient tumor samples. (A) Summary of RiboMeth-seq analysis depicted deviations from the average of the three RLN control samples. Statistically significant (n = 3) data points are labeled in blue and red, representing hyper- and hypomethylation, respectively. SSU: small ribosomal subunit; LSU: large ribosomal subunit. (B) Normalized expression levels of all rRNA targeting box C/D snoRNAs in DLBCL tumor samples and RLN controls. (C) Expression levels of three box C/D snoRNAs that varied in expression levels in parallel to changes in rRNA methylation levels. Bars represent mean values.