Table 3.
Segmented regression models under subtherapeutic categories
| Subtherapeutic categories | Time (P value) | Intervention (P value) | Time after intervention (P value) | Constant (P value) | Goodness of fit (R2) | No. of medicines |
|---|---|---|---|---|---|---|
| Classes with Schedule H1 formulations | ||||||
| cephalosporins | 0.012 (0.000) | −0.094 (0.199) | −0.012 (0.000) | 18.538 (0.000) | 0.989 | 47 |
| fluoroquinolones | 0.002 (0.093) | −0.123 (0.055) | −0.005 (0.007) | 17.256 (0.000) | 0.991 | 9 |
| other β-lactam antimicrobials | 0.014 (0.000) | 0.280 (0.005) | 0.002 (0.470) | 13.135 (0.000) | 0.988 | 6 |
| anti-TB | 0.002 (0.001) | −0.120 (0.003) | −0.006 (0.000) | 18.110 (0.000) | 0.996 | 17 |
| total Schedule H1 antimicrobials | 0.008 (0.000) | −0.08 (0.0054) | −0.009 (0.000) | 19.184 (0.000) | 0.986 | 83 |
| Classes without Schedule H1 formulations | ||||||
| broad-spectrum penicillins | 0.003 (0.002) | 0.021 (0.703) | −0.002 (0.296) | 18.848 (0.000) | 0.994 | 31 |
| medium- and narrow-spectrum penicillins | 0.006 (0.119) | −0.028 (0.907) | −0.007 (0.253) | 16.742 (0.000) | 0.947 | 7 |
| aminoglycosides | 0.003 (0.013) | −0.024 (0.759) | −0.023 (0.285) | 16.230 (0.000) | 0.991 | 8 |
| tetracycline and combinations | 0.004 (0.002) | 0.045 (0.500) | −0.011 (0.000) | 17.964 (0.000) | 0.981 | 12 |
| total antimicrobials outside Schedule H1 | 0.001 (0.089) | 0.009 (0.843) | −0.000 (0.898) | 20.318 (0.000) | 0.992 | 136 |
Schedule H1 cephalosporins include cefixime, cefdinir, cefpodoxime, ceftriaxone, ceftazidime, cefoperazone, cefepime, ceftizoxime, cefpirome, cefetamet, cefotaxime, cefditoren, ceftibuten and their combinations. Schedule H1 fluoroquinolones include balofloxacin, gemifloxacin, levofloxacin, moxifloxacin, prulifloxacin, sparfloxacin and their combinations. Schedule H1 ‘other β-lactam antibacterials’ include ertapenem, faropenem, imipenem, meropenem and their combinations. Schedule H1 anti-TB drugs include capreomycin, cycloserine, ethambutol, ethionamide, isoniazid, pyrazinamide, rifabutin, rifampicin and their combinations. ‘Total antimicrobials outside Schedule H1’ includes all antimicrobials belonging to classes not containing Schedule H1 antimicrobials and also antimicrobials left out of Schedule H1 in classes that include some Schedule H1 antimicrobials such as cephalosporins, fluoroquinolones etc.