Table 2.
Multivariable models inclusive of baseline characteristics and RVI fibrosis for the primary outcome
| Characteristics | Univariable | Model 1a | Model 2b | Model 3c | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HR | 95% CI | p value | HR | 95% CI | p value | HR | 95% CI | p value | HR | 95% CI | p value | |
| Demographics | ||||||||||||
| Age | 1.02 | 1.002–1.03 | 0.03 | |||||||||
| Systolic blood pressure | 0.99 | 0.98–0.997 | 0.01 | |||||||||
| Heart rate | 1.02 | 1.007–1.03 | 0.001 | 1.02 | 1.004–1.03 | 0.01 | 1.02 | 1.003–1.03 | 0.01 | |||
| Hypertension | 1.41 | 0.99–1.99 | 0.06 | |||||||||
| Diabetes | 2.33 | 1.62–3.37 | < 0.001 | 2.32 | 1.57–3.43 | < 0.001 | 1.97 | 1.32–2.94 | 0.001 | |||
| Hyperlipidemia | 1.74 | 1.21–2.51 | 0.003 | |||||||||
| NYHA 3–4 | 1.81 | 1.23–2.66 | 0.002 | |||||||||
| Medications | ||||||||||||
| ACEi/ARB | 2.41 | 1.33–4.36 | 0.004 | |||||||||
| Beta blocker | 2.20 | 1.21–3.98 | 0.009 | |||||||||
| Diuretics | 3.28 | 2.2–4.90 | < 0.001 | 2.18 | 1.37–3.47 | 0.001 | 1.84 | 1.14–2.96 | 0.01 | |||
| CMR variables | ||||||||||||
| LVEF | 0.95 | 0.94–0.97 | < 0.001 | 0.97 | 0.95–0.98 | < 0.001 | 0.98 | 0.96–0.995 | 0.01 | 0.97 | 0.95–0.99 | 0.001 |
| RVEF | 0.97 | 0.95–0.98 | < 0.001 | |||||||||
| LA volume index | 1.02 | 1.01–1.02 | < 0.001 | |||||||||
| RVI fibrosis | 2.11 | 1.48–2.99 | < 0.001 | 1.75 | 1.18–2.60 | 0.01 | 1.66 | 1.12–2.46 | 0.01 | 1.61 | 1.09–2.40 | 0.02 |
ACEi Angiotensin-converting enzyme inhibitors, ARB Angiotensin II receptor blocker, BP blood pressure, EF ejection fraction, LA left atrial, LV left ventricular, NYHA New York Heart Association, RV right ventricular, RVI right ventricular insertion point
aModel 1 represents multivariable Cox regression model with age, systolic BP, Heart rate, Hypertension, Diabetes, Hyperlipidemia, NYHA 3–4, LVEF, RVEF, indexed LA volume, RVI fibrosis (present or absent)
bModel 2 represents multivariable Cox regression model with age, systolic BP, Heart rate, NYHA 3–4, ACEi/ARB, Beta Blocker, Diuretics, LVEF, RVEF, indexed LA volume, RVI fibrosis (present or absent)
cModel 3 represents represents multivariable Cox regression model with age, Hypertension, Diabetes, NYHA 3–4, ACEi/ARB, Beta Blocker, Diuretics, LVEF, RVEF, indexed LA volume, RVI fibrosis (present or absent)