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. 2021 Jun 17;31:15. doi: 10.1186/s12610-021-00133-9

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 3 — Circulating AMH serum levels were predictive of negative sperm retrieval outcomes in individuals with Klinefelter syndrome-related spermatogenic failure undergoing testicular sperm extraction (TESE). a Dot plots depict values from the 6 positive sperm retrievals and 13 negative sperm retrievals in Klinefelter syndrome NOA; horizontal bars detail median values and interquartile ranges. Dashed lines represent the cut-off chosen for AMH. ♰ (p=0.01) positive versus negative TESE in individuals with Klinefelter syndrome NOA. Statistical analysis was performed by the two-tailed Mann Whitney U test. b ROC-derived curve showing the AUC, 95% CI (confidence intervals) and P-value. Red dot plots depict optimal AMH cut-off (2.5 pmol/l). Area under the ROC curve (AUC) = 0.84; (95% CI = 0.66 to 1; p= 0.01). For the AMH cut-off: sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV) and accuracy: 100%, 76.9%, 66.6%, 100% and 84.2%, respectively (p=0.003). AUC Area Under the Curve,95% CI95% confidence interval,NOA Nonobstructive azoospermia, ROC Receiver operating characteristic, TESE Testicular sperm extrac