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. 2021 Jun 17;23:76. doi: 10.1186/s12968-021-00767-8

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 1 — Experimental design and the numbers of subjects in each group. Rats received intravenous doxorubicin (1 mg/kg, twice a week). A total of 40 rats were consecutively enrolled into five groups (eight rats in each group; group 1: 2-week, 2: 4-week, 3: 6-week, 4: 8-week, 5: 12-week). Among them, two rats in group 1 and one each in groups 4 and 5 died during the specific treating period. Five control rats (group 0) that received normal saline intravenously (1 mg/kg, twice a week) were also included for comparison. Cardiovascular magnetic resonance (CMR) scans (blue circles) were performed in the short-axis planes in each group. All rats were sacrificed for histopathologic evaluation immediately after the CMR scan. The association between the CMR parameters and the histopathological changes was assessed