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. 2021 Jun 17;23:76. doi: 10.1186/s12968-021-00767-8

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 4 — Univariable regression analysis between native T1 or ECV and histopathological findings. Groups 1 (2 week), gray circle; 2 (4 week), emerald circle; 3 (6 week), red circle; 4 (8 week), blue circle; and 5 (12 week), black circle indicates the subjects undergoing 2, 4, 6, 8, and 12 weeks of treatment. Group 0 (control), open circle indicates the control subjects. a–d The native T1 value showed significant association with the vacuolar change (a, R = 0.60, P < 0.001), fibrosis (b, R = 0.38, P = 0.02), inflammation score (c, R = 0.45, P = 0.004), and myocardial edema score (d, R = 0.49, P = 0.001). e–h ECV value showed significant association with the vacuolar change (e, R = 0.70, P < 0.001), fibrosis (f, R = 0.78, P < 0.001), inflammation score (g, R = 0.33, P = 0.04), and myocardial edema score (h, R = 0.42, P = 0.008)