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. 2021 Jun 17;23:76. doi: 10.1186/s12968-021-00767-8

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 5 — CMR data and histopathological findings of doxorubicin-treated rats. a–c For a representative rat at 6 weeks of doxorubicin treatment (group 3) with a left ventricular ejection fraction (LVEF) of 65%, global native T1 of 1401 ms, and ECV of 21.3%, there were marked vacuolar changes (arrowheads) of the myocytes with a mean value of 32.9% (a, Masson’s trichrome stain, × 200). Interstitial fibrosis was 3.0% (b, picrosirius red stain, × 100). There were interstitial edema (median score: 2) and infiltration of lymphohistiocytic aggregates (arrows, median score: 2) around the injured myofibers (c, hematoxylin, and eosin stain, × 200). d–f For a representative rat at 12 weeks of doxorubicin treatment (group 5) with a LVEF of 67%, global native T1 of 1410 ms, and ECV of 28.9%, there were multifocal vacuolar degenerations in the myocytes (arrowheads) with a mean vacuolar change of 38.0% (d, Masson’s trichrome stain, × 200). Interstitial fibrosis was severe, with a mean value of 25.4% (e, picrosirius red stain, × 100). Interstitial edema (median score: 1.75) and scattered lymphocytic infiltration (arrows, median score: 0.25) were also present (f, hematoxylin and eosin stain, × 200)