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. 2021 Jun 16;14:162. doi: 10.1186/s12920-021-01007-9

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 1 — Landscape around four example IA-associated LD blocks showing enhancer marks in three cell types. HUVECs in blue, fibroblasts (lung) in green, SMCs in purple. IA-associated LD block in orange, index SNP is yellow line. “†” denotes significance. Relative height of ChIP-seq peaks all scaled from 0–10 in Genome Browser. A Genome browser screenshot showing the IA-associated LD block identified by the intergenic tap SNP rs1429412 near ANKRD44. All three marks (H3K27ac, H3K4me1, and H3K9ac) were present for both HUVECs and fibroblasts. B Genome browser screenshot showing the IA-associated LD block for the IL6 locus identified by the intronic tag SNP, rs1800796. All three marks are present for HUVECs. C Genome browser screenshot showing the IA-associated LD block identified by the intergenic tag SNP rs10757278 near CDKN2B-AS1. All three marks were present for HUVECs. D Genome browser screenshot showing the IA-associated LD block for the FGD6 locus identified by intronic tag SNP, rs6538595. All three marks were present for HUVECs