Table 3.
Differentially expressed genes in IA tissue present within IA risk associated TADs
| HUVEC TAD | Fib. (IMR90) TAD | |||
|---|---|---|---|---|
| Gene (TAD found in) | IA versus Ctr | R versus UR | IA versus Ctr | R versus UR |
| BFSP1 (rs1132274) | Kleinloog (↓, − 4.0) | |||
| Nakaoka (↓, − 1.8) | ||||
| CASD1 (rs42524) | Kurki (↓, − 1.0) | |||
| CDKN2A (rs2891168, rs10757278) | Wang (↑, NR) | Nakaoka (↓, − 1.9) | Wang (↑, NR) | Nakaoka (↓, − 1.9) |
| CDKN2B (rs2891168, rs10757278) | Wang (↑, NR) | Wang (↑, NR) | ||
| COL1A2 (rs42524) | Li (↑, NR) | Li (↑, NR) | ||
| Wang (↑, NR) | Wang (↑, NR) | |||
| COL3A1 (rs1800255) | Li (↑, NR) | Li (↑, NR) | ||
| Wang (↑, NR) | Wang (↑, NR) | |||
| COL5A2 (rs1800255) | Li (↑, NR) | |||
| Shi (↑, 3.3) | ||||
| Wang (↑, NR) | ||||
| DSTN (rs1132274) | Wang (↓, NR) | |||
| GULP1 (rs1800255) | Kurki (↓, − 2.2) | Kurki (↓, − 2.2) | ||
| Nakaoka (↓, − 1.3) | Nakaoka (↓, − 1.3) | |||
| IL6 (rs1800796) | Kurki (↑, 2.2) | Kurki (↑, 2.2) | ||
| KLHL7 (rs1800796) | Nakaoka (↑, 0.50) | Nakaoka (↑, 0.50) | ||
| MEOX2 (rs4628172) | Wang (↓, NR) | Wang (↓, NR) | ||
| MOB4 (rs1429412) | Wang (↓, NR) | Wang (↓, NR) | ||
| PDK4 (rs42524) | Wang (↓, NR) | Kurki (↑, 1.0) | ||
| PLCL1 (rs700651) | Kleinloog (↓, − 4.0) | Kleinloog (↓, − 4.0) | ||
| Kurki (↓, − 1.4) | Kurki (↓, − 1.4) | |||
| PPP1R9A (rs42524) | Wang (↓, NR) | |||
| RRBP1 (rs1132274) | Wang (↑, NR) | |||
| SGCE (rs42524) | Wang (↓, NR) | Kurki (↓, − 2.3) | ||
| SNX5 (rs1132274) | Wang (↑, NR) | |||
| SOX17 (rs10958409, rs9598506) | Wang (↓, NR) | Nakaoka (↑, 0.88) | ||
| TFPI (rs1800255) | Wang (↓, NR) | |||
| TMEM167A (rs251124) | Kurki (↑, 1.2) | Kurki (↑, 1.2) | ||
| TOMM7 (rs1800796) | Kurki (↓, − 0.86) | Kurki (↓, − 0.86) | ||
| VCAN (rs251124) | Shi (↑, 2.9) | Shi (↑, 2.9) | ||
| Wang (↑, NR) | Wang (↑, NR) | |||
| XRCC4 (rs251124) | Kleinloog (↑, 2.3) | Kleinloog (↑, 2.3) | ||
The log2(fold-change) for each gene as reported in the respective study is shown in parentheses. If study did not provide fold-change, NR is reported. Multiple probes corresponded to Nakaoka’s CDKN2A; average value was reported
Ctr., control; Fib., fibroblast; HUVEC, human umbilical vein endothelial cell; IA, intracranial aneurysm; NR, not reported; R, ruptured; TAD, topologically associated domain; UR, unruptured