Table 1. Antinociceptive Effect of Thiowurtzine in the Acetic Acid Writhing Test (X ± m)a.
| group | number of writhings within 20 min | writhing latency, s | pain response inhibition, % |
|---|---|---|---|
| Series I: Inbred Male CBA Mice. Single Administration of Thiowurtzine and Tramadol | |||
| (1) negative control—vehicle (n = 9) | 24.1 ± 3.4 | 160.9 ± 86.4 | 0 |
| (3) tramadol, 20 mg/kg (n = 9) | 9.1 ± 2.0, **(1–3) | 444.8 ± 42.8, **(1–3) | 62.2 |
| (5) thiowurtzine, 100 mg/kg (n = 6) | 10.5 ± 3.0, *(1–5) | 382.5 ± 120.4, *(1–5) | 56.4 |
| Series II: Outbred Male Mice, Stock CD1. Drug Administration for 4 days | |||
| (1) negative control—vehicle (n = 10) | 27.4 ± 3.1 | 276 ± 15 | |
| (2) diclofenac, 10 mg/kg (n = 10) | 18.2 ± 1.2, **(1–2) | 270 ± 10 | 33.6 |
| (3) thiowurtzine, 50 mg/kg (n = 10) | 11.8 ± 2.9, **(1–3), *(2–3) | 270 ± 10 | 56.9 |
| (4) thiowurtzine, 100 mg/kg (n = 10) | 14.5 ± 3.0, **(1–4) | 273 ± 16 | 47.1 |
a
*p < 0.05, **p < 0.01 compared to the negative control and the reference group (Mann–Whitney U test).