Table 2. Analgesic Activity of Thiowurtzine in the Hot Plate Test in Outbred Male Stock CD Rats (X ± m)^a.

group	pain response latency, s	pain response inhibition, %
Series I: Drug Administration for 4 days
(1) negative control—vehicle (n = 8)	9.8 ± 1.0
(2) diclofenac, 5 mg/kg (n = 9)	10.9 ± 1.5	11.3
(3) thiowurtzine, 25 mg/kg (n = 9)	10.4 ± 1.3	6.1
(4) thiowurtzine, 50 mg/kg (n = 8)	12.1 ± 1.6	23.5
Series II: Drug Administration for 4 days
(1) negative control—vehicle (n = 10)	11.3 ± 1.0
(2) thiowurtzine, 100 mg/kg (n = 10)	20.1 ± 2.3, **(1–2)	77.9
(3) thiowurtzine, 200 mg/kg (n = 10)	14.9 ± 2.1, *(2–3)	31.9
(4) thiowurtzine, 300 mg/kg (n = 10)	13.2 ± 2.7	16.8

^a*p < 0.05, **p < 0.01 compared to the negative control and the reference group (Mann–Whitney U test).