Table 3. Analgesic Activity of Thiowurtzine in the Randall–Selitto Test in Outbred Male Stock CD1 Mice (X ± m)^a.

	supporting pressure in the left hind paw pad, g/condition		supporting pressure in the right hind paw pad with formalin edema, g/condition
group	1 h after drug administration	4 h after drug administration	1 h after drug administration, 1–5 min after injection of formalin	1 h after drug administration, 40–50 min after injection of formalin
(1) negative control—vehicle (n = 10)	294.9 ± 48.4	373.2 ± 70.9	141.1 ± 23.7	305.2 ± 72.6
(2) tramadol, 10 mg/kg (n = 9)	645.2 ± 40.8, **(1–2)	606.7 ± 53.9, **(1–2)	318.9 ± 84.1, *(1–2)	518.0 ± 85.0, *(1–2)
(3) ketorolac, 6 mg/kg (n = 8)	521.2 ± 107.9, **(1–3)	449.7 ± 90.4	491.4 ± 88.2, *(1–3)	396.6 ± 94.1
(4) thiowurtzine, 100 mg/kg (n = 9)	631.5 ± 43.9, **(1–4)	612.9 ± 43.8, **(1–4)	620.8 ± 60.0, **(1–4)	611.3 ± 58.8, **(1–4)
(5) thiowurtzine, 200 mg/kg (n = 9)	586.1 ± 68.6, **(1–5)	455.8 ± 81.7	419.7 ± 94.2, *(1–5)	366.3 ± 88.3

^a*p < 0.05, **p < 0.01 compared to the negative control and the reference group (Mann–Whitney U test).