. 2021 May 31;6(23):15400–15411. doi: 10.1021/acsomega.1c01786

Table 4. Docking Scores of Thiowurtzine and Control Drugs against the Mu, Kappa, Delta, and ORL1 Opioid Receptors, the TRPA1 and TRPV1 Ion Channels, and the Ca_v 1.2 Calcium Channel^a.

drug	GOLD score with the mu receptor	GOLD score with the kappa receptor	GOLD score with the delta receptor	GOLD score with the ORL1 receptor	GOLD score with the TRPA1 receptor	GOLD score with the TRPV1 receptor	GOLD score with the Ca_v 1.2 receptor
tramadol 1S-2S	19,546	27,003	21,797	20,520	24,965	21,236	24,499
tramadol 1R-2R	19,188	28,349	20,435	19,272	23,058	21,497	23,597
ketorolac	19,529	26,150	23,640	19,467	23,712	19,717	22,065
diclofenac	20,823	31,603	24,274	17,567	22,406	20,449	24,154
thiowurtzine	8,465	2,730	6,407	2,153	14,831	8,414	15,562

The scores of the GOLD³⁸ docking software using the Chemscore^40,41 rescore function are displayed.

Table 4. Docking Scores of Thiowurtzine and Control Drugs against the Mu, Kappa, Delta, and ORL1 Opioid Receptors, the TRPA1 and TRPV1 Ion Channels, and the Cav 1.2 Calcium Channela.