TABLE 3.
Laboratory findings on admission of patients with COVID-19 treated with and without antimalarial drugs in a tertiary care center in Mexico City.
| Characteristic | N | Overall (N = 497) | HCQ/CLQ (N = 211) | No antimalarial (N = 286) | p-value |
|---|---|---|---|---|---|
| Hemoglobin, g/dl | 617 | 15.3 ± 2.0 | 15.4 ± 1.9 | 15.3 ± 2.0 | 0.41 |
| Leukocytes, × 103/µl | 615 | 7.9 (5.8–11.0) | 7.1 (5.3–9.9) | 8.2 (6.1–12.4) | 0.001 |
| Absolute neutrophil count | 613 | 6,438 (4,468–9,523) | 5,833 (4,026–8,483) | 6,757 (4,802–10,545) | <0.001 |
| Absolute lymphocyte count | 613 | 800 (558–1,057) | 806 (560–1,078) | 799 (558–1,041) | 0.094 |
| Platelets, K/µl | 615 | 214 (174–275) | 204 (165–256) | 226 (179–292) | 0.001 |
| BUN, mg/dl | 617 | 15.4 (11.1–22.8) | 14.3, (10.6–20.1) | 16.0 (11.6–23.9) | 0.006 |
| Creatinine, mg/dl | 617 | 0.9 (0.8–1.2) | 0.9 (0.8–1.2) | 1.0 (0.8–1.2) | 0.53 |
| Total bilirubin, mg/dl | 608 | 0.7 ± 0.5 | 0.7 ± 0.5 | 0.7 ± 0.5 | 0.31 |
| Albumin, g/dl | 607 | 3.7 ± 0.5 | 3.8 ± 0.5 | 3.6 ± 0.5 | 0.004 |
| Globulin, g/dl | 604 | 3.3 ± 0.5 | 3.2 ± 0.5 | 3.3 ± 0.5 | 0.002 |
| ALT, u/l | 608 | 36 (24–55) | 34 (23–53) | 38 (25–58) | 0.11 |
| AST, u/l | 608 | 43 (30–64) | 41 (27–60) | 44 (31–66) | 0.026 |
| ALP, u/l | 608 | 88 (70–114) | 82 (67–106) | 92 (74–118) | <0.001 |
| LDH, u/l | 573 | 382 (290–504) | 348, (261–479) | 395, (313–537) | <0.001 |
| CRP, mg/dl | 596 | 14 (7–22) | 13 (5–20) | 15 (8–23) | <0.001 |
| CPK, u/l | 538 | 116 (63–239) | 112 (61–238) | 116 (64–245) | 0.79 |
| Ferritin, ng/ml | 588 | 629 (320–1,066) | 539 (250–910) | 704 (350–1,105) | 0.004 |
| Fibrinogen, mg/dl | 508 | 688 (499–834) | 618 (468–774) | 715 (554–883) | <0.001 |
| D-dimer, ng/ml | 584 | 701 (437–1,138) | 568 (390–1,020) | 770 (595–1,208) | <0.001 |
| Troponin I, pg/ml | 532 | 5.5 (3.6–11.4) | 5.0 (3.5–7.3) | 6.1 (3.8–13.6) | <0.001 |
| pO2, mmHg | 599 | 62.9 (54.0–77.8) | 63.8 (55.2–76.0) | 62.5 (52.8–76.0) | 0.077 |
| Lactate, mmol/L | 470 | 1.3, (1.0–1.9) | 1.2, (0.9–1.6) | 1.5, (1.1, 2.1) | <0.001 |
| PaO2/FiO2 index | 595 | 209 (124–266) | 235 (160–281) | 185 (109–250) | <0.001 |
HCQ, hydroxychloroquine; CLQ, chloroquine; BUN, blood urea nitrogen; ALT, alanine transaminase; AST aspartate transaminase; ALP, alkaline phosphatase; LDH, lactate dehydrogenase; CRP, C reactive protein; CPK, creatine phosphokinase; pO2, partial pressure of oxygen; FiO2, fraction of inspired oxygen. Bold values are the statistically significant variables.