Figure 3. Pioglitazone reduces brain vulnerability to ischemia after TBI.
A) Representative TTC staining after MCAO from mice that first underwent control or TBI and were treated with pioglitazone (Pio; 10 mg/kg) or vehicle (Veh). B) Mice that were treated with Pio after TBI has infarct volumes similar to mice that did not have a TBI prior to MCAO. C) Treatment with PIO prevented the TBI exacerbation of right-biased turning in the corner test. An asterisk (*) indicates significance at p < 0.05.