FIGURE 4: Treatment and follow-up of syphilis and neurosyphilis cases.

Source: adapted from Clinical Protocol and Therapeutic Guidelines for Comprehensive Care for People with Sexually Transmitted Infections, 2020 ¹³ .

Notes: a) Benzathine benzylpenicillin is the only safe and efficient option for adequate treatment of pregnant women. Any other treatment conducted during pregnancy, for purposes of defining the case and therapeutic approach of congenital syphilis, is deemed inadequate treatment for the mother; consequently, the newborn will be notified as having congenital syphilis undergo clinical and laboratory assessment; b) The interval between doses must not be longer than 14 days. In such a case, the scheme must restart ¹⁹ .