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. Author manuscript; available in PMC: 2021 Jun 17.
Published in final edited form as: Prog Retin Eye Res. 2018 Mar 22;65:28–49. doi: 10.1016/j.preteyeres.2018.03.003

Figure 2. AAV serotype transduction comparison following subretinal injection in mouse retina.

Figure 2.

A) Schematic digram depicting the layers of the neural retinal and placement of AAV vectors in vivo. B-H) Immunohistochemical analysis of GFP expression (green) driven by seven different AAV serotypes two weeks post-subretinal injection. Representative z-stacks are shown for each of AAV1 (B-B’), AAV2 (C-C’), AAV4 (D-D’), AAV5 (E-E’), AAV6 (F-F’), AAV8 (G-G’) and AAV9 (H-H’). DAPI was used to visualize retinal nuclei. NFL – nerve fiber layer, GCL – ganglion cell layer, IPL – inner plexiform layer, INL – inner nuclear layer, OPL – outer plexiform layer, ONL – outer nuclear layer, IS/OS – photoreceptor cell inner and outer segments. Scale bars = 50 μm.