. 2021 Jun 4;12(15):4655–4660. doi: 10.7150/jca.51038

Table 1.

Correlations between CD73 or CD8 and clinicopathological features in 140 ICC

Variables	CD73^low	CD73^high	P value	CD8^high	CD8^low	P value
Age (years)
≥ 53	33	37	0.499	33	37	0.865
<53	37	33	0.499	32	38	0.865
Sex
Male	25	34	0.171	25	34	0.412
Female	45	36	0.171	40	41	0.412
HBsAg
Positive	41	46	0.384	42	45	0.574
Negative	29	24	0.384	23	30	0.574
Liver cirrhosis
Yes	26	31	0.390	25	32	0.614
No	44	39	0.390	40	43	0.614
Serum CA19-9 (ng/ml)
≥37	44	41	0.604	41	44	0.594
<37	26	29	0.604	24	31	0.594
Serum ALT (U/l)
≥75	12	7	0.217	9	10	0.930
<75	58	63	0.217	56	65	0.930
Child-Pugh score
A	71	63	0.511*	63	71	0.686*
B	4	2	0.511*	2	4	0.686*
Serum AFP (ng/ml)
<20	63	59	0.313	52	70	0.019
≥20	7	11	0.313	13	5	0.019
Tumor size (diameter, cm)
≤5	57	52	0.309	56	53	0.028
>5	13	18	0.309	9	22	0.028
Tumor differentiation
III/IV	41	31	0.091	34	34	0.410
I/II	29	39	0.091	31	41	0.410
Tumor number
Multiple	5	6	0.753	4	7	0.517
Single	65	64	0.753	42	87	0.517
Microvascular/bile duct invasion
Yes	8	15	0.110	4	7	0.544*
No	62	55	0.110	61	68	0.544*
Lymphatic metastasis
Yes	12	22	0.049	21	13	0.039
No	58	48	0.049	44	62	0.039

Abbreviations and Note: ICC, intrahepatic cholangiocarcinoma; AFP, alpha-fetoprotein; HBsAg, hepatitis B surface antigen; X² test. CD73^high, ≥50% of tumor section, and CD73^low, <50%. *Fisher's Exact Test.