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. 2021 Jun 4;12(15):4661–4671. doi: 10.7150/jca.53115

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ApoM gene inhibits tumor formation rate and liver cancer cell cycle in nude mice. (A)The tumor formation experiment in nude mice showed that the same number of cells were injected subcutaneously in the two groups. Compared with the tumors in the Hepa1-6-control group, the tumors grew faster in Hepa1-6-ApoM^-/-. (B)The ApoM^-/- model in nude mouse tumors was successfully constructed by Western blot analysis. (C)The tumor growth size of nude mice showed that in the sixteenth day, the tumor in the Hepa1-6-ApoM^-/- group was larger than that in the Hepa1-6-control group (P=0.00078). (D) Using cell cycle experiments to analyze the ApoM gene deletion group, the sum of G0/G2 and S phase is larger, and the proliferation rate is faster; the ApoM gene overexpression group, the G0/G1 phase is blocked and the proliferation rate is slower. (E) Similarly, the cell cycle test of Huh-7-ApoM^-/- model and Huh-7-ApoM-OP model is consistent with the above conclusions.