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. 2021 Jun 4;12(15):4661–4671. doi: 10.7150/jca.53115

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The deletion of ApoM gene aggravate the migration and invasion of Hepa1-6 liver cancer cells. (A) The Transwell migration experiment indicated that the ApoM gene deletion group had stronger migration ability than the control group (P=0.000044), while the overexpression group decreased (P=0.00018). (B) The Transwell invasion experiment indicated that the ApoM gene deletion group had stronger invasion ability (P=0.000025), while the overexpression group decreased (P=0.00042). (C) Western blot analysis was used to analyze that the ApoM gene deletion group had a higher MMP-2 protein expression level (P=0.027), and the overexpression group was the opposite (P=0.027). All data were ± s of 3 independent measurements, n≥3, *p<0.05, **p<0.03, ***p<0.01.

Inline graphic — The deletion of ApoM gene aggravate the migration and invasion of Hepa1-6 liver cancer cells. (A) The Transwell migration experiment indicated that the ApoM gene deletion group had stronger migration ability than the control group (P=0.000044), while the overexpression group decreased (P=0.00018). (B) The Transwell invasion experiment indicated that the ApoM gene deletion group had stronger invasion ability (P=0.000025), while the overexpression group decreased (P=0.00042). (C) Western blot analysis was used to analyze that the ApoM gene deletion group had a higher MMP-2 protein expression level (P=0.027), and the overexpression group was the opposite (P=0.027). All data were ± s of 3 independent measurements, n≥3, *p<0.05, **p<0.03, ***p<0.01.