Table 2.

Uni- and multivariate Cox regression analysis for overall survival in the SGH cohort

	Univariate analysis		Multivariate analysis
			TSP-manuala		TSP-cad(50%)		TSP-cad(median)
	HR	95%CI	HR	95%CI	HR	95%CI	HR	95%CI
Age (years)
<65	1
≥65	2.368	1.646-3.407
Gender
Male	1
Female	0.613	0.413-0.909
TNM Stage
I+II	1		1		1		1
III+IV	3.54	2.404-5.212*	1.176	0.457-3.023	1.198	0.473-3.037	1.241	0.501-3.075
Depth of invasion
T1+T2	1		1		1		1
T3+T4	2.878	1.504-5.506*	1.401	0.771-2.762	1.402	0.711-2.765	1.383	0.701-2.729
LN metastasis
N0	1		1		1		1
N1+N2	3.724	2.516-5.512*	2.372	0.908-6.197	2.349	0.912-6.049	2.228	0.884-5.615
Nerve invasion
NO	1		1		1		1
YES	2.298	1.575-3.353*	1.397	0.917-2.130	1.421	0.943-2.164	1.413	0.928-2.152
Vessel invasion
NO	1		1		1		1
YES	2.684	1.858-3.875*	1.575	1.034-2.400*	1.565	1.028-2.383*	1.574	1.034-2.398*
Differentiation status
Well	1		1		1		1
Moderate+poor	2.574	1.050-6.312*	1.964	0.795-4.851	1.986	0.804-4.910	1.957	0.799-4.877
Tumor size
<5 cm	1
≥5 cm	1.287	0.889-1.862
Tumor location
Right	1		1		1		1
Left and rectal	0.502	0.348-0.723*	0.498	0.342-0.725*	0.492	0.329-0.717*	0.486	0.334-0.707*
TSP-manuala
TSP-low	1		1
TSP-high	1.75	1.214-2.523*	1.516	1.048-2.193*
TSP-cad(50%)
TSP-low	1				1
TSP-high	1.659	1.145-2.405*			1.452	0.999-2.111*b
TSP-cad(median)
TSP-low	1						1
TSP-high	1.823	1.239-2.683*					1.608	1.089-2.375*

^aPathology consensus;

^bDuo to P-values is 0.051,which is near to 0.05, and shall be considered to siginificant results (P<0.05);

Abbreviations: HR: hazard ratio; CI: confidence interval; LN metastasis:Lymph node metastasis.

*P < 0.05.