Table 6.

TSP-high was associated with TNM stage and lymph node metastasis in comparison to TSP-low in SGH, Training, Testing, TMA internal, TCGA external cohort

	TSP-manual	TSP-cad (50%)	TSP-cad(median)
	p value
SGH cohort	0.024*	0.025*	0.004*
Training cohort	0.423	0.323	0.052
TNM stage
Testing cohort	0.003*	0.008*	0.023*
TMA cohort	0.001*	NA	0.001*
TCGA cohort	0.024*	NA	0.032*
SGH cohort	0.035*	0.035*	0.005*
Training cohort	0.367	0.258	0.063
Lymph node
Testing cohort	0.012*	0.026*	0.023*
Metastasis
TMA cohort	0.001*	NA	0.002*
TCGA cohort	0.028*	NA	0.036*

Abbreviations: NA, not applicable. Due to we do not evaluate TSP using MATLAB of CAD system in the TMA and TCGA cohort, thus we lack of TSP-cad(50%)data in TMA and TCGA cohort.

*P < 0.05.