Scheme 5.
Total synthesis of Omtriptolide and Minnelide. ⅰ) HO2C(CH2)nCO2H, DCC/DMAP; ⅱ) n=2; ⅲ) Me2S, MeCN, BPO, 2 h; ⅳ) CH2Cl2, 4A MS, (BnO)2P(O)OH, NIS, THF; ⅴ) H2, Pb/C, THF; ⅵ) THF, Na2CO3.
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