Table 2.
Related research on triptolide and its derivatives.
| Compound | Chemical structure | Aqueous solubility | Pharmacological activity | Refs |
|---|---|---|---|---|
| Triptolide (PG490, LDTT-2) |  |
Poor Solubility | Anti-cancer, anti-inflammatory and immunosuppression |
22, 23 4 |
| Omtriptolide (PG490-88, F60008) |  |
Soluble | Anti-cancer, immunosuppression, inhibition of pro-inflammatory mediators and cytokines |
4 146 |
| (5R)-5-Hydroxytriptolide (LLDT-8) |  |
Soluble | Immunosuppression and anti-inflammatory effects | 151, 155 |
| Minnelide |  |
Soluble | Extensive anti-cancer effects enhance the efficacy of chemotherapy drugs | 160, 168 |