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. 2021 May 25;11(15):7379–7390. doi: 10.7150/thno.58781

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Cytokine expression level changes in PBAMs treated with SKF-96365 following SARS-CoV-2 S treatment under febrile temperature. (A-C) Cytokine array analysis showing significant changes in the expression of multiple proteins. Twelve cytokines, including IFN-α (p < 0.01), IFN-γ (p < 0.01), IL-13 (p < 0.01), IL-α (p < 0.05), TNF-α (p < 0.01), IL-10 (p < 0.01), IL-18 (p < 0.01), IL-2 (p < 0.01), IL-4 (p < 0.01), IL-17A (p < 0.01), MCP-1 (p < 0.05), and IL-15 (p < 0.05) exhibited robustly decreased expression in the His - S-RBD-SKF-96365 group (10 µM) vs. His - S-RBD-DMSO group at 39.5 °C. Data are shown as the mean ± SD (n = 3). *p < 0.05.**p < 0.01. NS: not significant.