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. 2021 May 24;11(15):7235–7246. doi: 10.7150/thno.52934

Figure 1.

Figure 1

Identification of Sirt5 as a positive regulator of type I interferon expression. (A) Q-PCR analysis of Ifnβ mRNA in BMDMs transfected with siRNA specific for Sirt1-7 for 48 h and then infected with VSV for 6 h. The results are normalized to Gapdh expression. (B-D) ELISA for IFN-β in supernatant of BMDMs transfected with Sirt5-siRNA for 48 h and then infected with VSV (B), SeV (C), and HSV (D) for the indicated durations. Data are presented as mean ± standard deviation (SD) of three independent experiments. (* P < 0.05).